Diltiazem-cyclosporin pharmacokinetic interaction - dose-response relationship
نویسندگان
چکیده
منابع مشابه
Diltiazem co-treatment in renal transplant patients receiving microemulsion cyclosporin.
BACKGROUND Usage of cyclosporin (the Hong Kong Hospital Authority's single largest item of drug expenditure) continues to increase, mainly due to increasing numbers of renal allograft patients taking it as long-term antirejection therapy. Diltiazem, an antihypertensive agent, interferes with the first pass extraction of oral cyclosporin, thus serving to conserve its dosage. AIMS In renal tran...
متن کاملPharmacokinetic advantage of intra-arterial cyclosporin A delivery to vascularly isolated rabbit forelimb. II. Dose dependence.
A vascularly isolated rabbit forelimb model simulating conditions of composite tissue allografting was used to determine the regional pharmacokinetic advantage achievable in extremity tissue components during i.a. cyclosporin A (CSA) administration. CSA was infused continuously via osmotic minipump into the right brachial artery of New Zealand rabbits at multiple doses ranging from 1.0 to 8.0 m...
متن کاملDose-response relationship for breast cancer induction at radiotherapy dose
PURPOSE Cancer induction after radiation therapy is known as a severe side effect. It is therefore of interest to predict the probability of second cancer appearance for the patient to be treated including breast cancer. MATERIALS AND METHODS In this work a dose-response relationship for breast cancer is derived based on(i) the analysis of breast cancer induction after Hodgkin's disease,(ii) ...
متن کاملDose-response relationship in multistage carcinogenesis: promoters.
Published dose-response curves of promoters of multistage carcinogenesis were selected that met the combined criteria of long study times, multiple doses, and low doses. In rat liver, 12 dose-response studies of 7 different promoters (phenobarbital, 2,3,7,8-tetrachlorodibenzo-p-dioxin [TCDD], clophen A-50 (a polychlorinated biphenyl), alpha-, beta-, and gamma-hexachlorocyclohexane [HCH], and ch...
متن کاملEmg Biofeedback Ii: the Dose—response Relationship
36 clients with anxiety neurosis were trained to reduce frontalis muscle tension over two phases of ten sessions each. They were assessed on psychological and physiological measures, before, during and after the phases. The data analysis indicated that the clients succeeded in lowering frontalis muscle tension levels during the feedback and no-feedback phases of the training sessions. The inter...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: British Journal of Clinical Pharmacology
سال: 1997
ISSN: 0306-5251
DOI: 10.1046/j.1365-2125.1997.t01-1-00616.x